Antimicrobial peptides development from host defense peptides (HDPs) of the Scarabaeidae family coleopterans and their evaluation against microorganisms that cause infections associated with health care.

Project: Research project

Project Details

Description

Drug resistance of microorganisms is today one of the greatest threats to global health and food safety. One of the key strategies to tackle this problem is the search for and/or development of new molecules with antimicrobial activity. Host defence peptides (HDPs) have become relevant in the development of future therapeutic applications, potential in agriculture and vector-borne disease control. In this work we propose to design, characterise and evaluate the antimicrobial capacity of synthetic and modified analogues of HDPs identified in coprophagous beetles. For this purpose, the susceptibility of clinical isolates and reference bacterial strains of the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae), E. coli, the mycobacterium Mycobaterium tuberculosis, the yeasts Candida albicans and Cryptococcus neoformans, of the different peptides designed. Those peptides with the best in vitro activity will be evaluated in a murine (in vivo) model of tuberculosis and disseminated candidiasis. In this way we will be able to develop new molecules with the potential to develop new drugs that can tackle micro-organisms of importance in health care.

Keywords

Antimicrobials
Chemical Synthesis
Design
Antimicrobial Cationic Peptides
Antimicrobial Resistance
Host Defense Peptides
In vitro
In vivo
StatusActive
Effective start/end date1/30/201/30/23

Main Funding Source

  • National